4-hydroxy-2-mercapto-6-methylpyrimidine

Structural formula

Business number	0173
Molecular formula	C5H6N2OS
Molecular weight	142.18
label	6-Methyl-2-thiouracil, MZU

Numbering system

CAS number:56-04-2

MDL number:MFCD00006040

EINECS number:200-252-3

RTECS number:YR0875000

BRN number:115648

PubChem number:24895573

Physical property data

1. Character:White crystal. in326-331℃ decomposition. Saturated aqueous solution is neutral or slightly acidic to litmus. Odorless, bitter, easy to sublime.

2. Density (g/mL,25/4℃): Unknown OK

3. Relative vapor density (g/mL,AIR=1): Undetermined

4. Melting point (ºC):330℃

5. Boiling point (ºC,Normal pressure): Undetermined

6. Boiling point (ºC, 1.60kPa): Undetermined.

7. Refractive index: Undetermined

8. Flash Point (ºC): Undetermined

9. Specific optical rotation (º): Undetermined

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa,25ºC): Undetermined

12. Saturated vapor pressure (kPa,60ºC): Undetermined

13. Heat of combustion (KJ/mol): Undetermined

14. Critical temperature (ºC): Undetermined

15. Critical pressure (KPa): Undetermined

16. Oil and water (octanol/Log value of water) partition coefficient: Undetermined

17. Explosion limit (%,V/V): Undetermined

18. Lower explosion limit (%,V/V): Undetermined

19. Solubility:Easily soluble in ammonia solution and sodium hydroxide solution, slightly soluble in alcohol and acetone, very slightly soluble in water and ether, insoluble in benzene and chloroform.

Toxicological data

None

Ecological data

None

Molecular structure data

1. Molar refractive index: 37.31

2. Molar volume (m³/ mol):103.1

3. isotonic specific volume (90.2K):296.7

4. Surface Tension (dyne/cm):68.3

5. Polarizability（10^-24cm³):14.79

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP):-0.2

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 1

4. Number of rotatable chemical bonds: 0

5. Number of tautomers: 6

6. Topological molecular polar surface area (TPSA):41.1

7. Number of heavy atoms: 9

8. Surface charge: 0

9. Complexity: 197

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. The number of uncertain atomic stereocenters: 0

13. Determine the number of stereocenters of chemical bonds: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

None

Synthesis method

It is derived from the reaction of ethyl acetoacetate and thiourea. Dissolve thiourea in sodium hydroxide solution, add ethyl acetoacetate dropwise, and control the temperature at 37℃below. After reacting 2h, add water and activated carbon, stir at 70-80℃Decolorization 0.5h. Filter, acidify the filtrate with hydrochloric acid to pH4-5, cool to room temperature, filter and wash. The filter cake is recrystallized with water to obtain the finished product. The yield is 66%. During production, ethyl acetoacetate and thiourea can also be mixed first, and then sodium oxide solution is added dropwise; anhydrous sodium carbonate can also be used instead of sodium hydroxide, and the yield is roughly the same.

Purpose

Intermediate of cardiovascular drug dipyridamole